Her Orthodox Jewish family was totally averse to her having an entertainment career. Her parents and grandparents forced her to leave the Theatre Guild school (New York) while still a teenager and had their wills drawn up accordingly so as to discourage this career choice.

Studied drama at Columbia University, and belonged to the American Theatre Wing.

When Mae was 17 and living in the South Bronx, she won a local contest to find the girl who most resembled Helen Kane, a popular singer known as the “Boop-Oop-A-Doop Queen”. She was promptly signed by an agent and began performing in the Vaudeville circuit. Billing herself as “Mae Questel – Personality Singer of Personality Songs,” she performed dead-on vocal imitations of Maurice Chevalier, Eddie Cantor, Fanny Brice, Marlene Dietrich, Mae West and of course Helen Kane, among many others. Her mimic talent also provided duck, dog, chicken, owl, monkey, lion and baby sounds for radio shows.